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The synthetic drug 3-Chloromethcathinone (3-CMC), commonly referred to as clophedrone, is a member of the cathinone class of psychoactive substances. Its structure is quite similar to that of other methcathinone derivatives, including 3-MMC and 4-CMC.

3-CMC, which is only made chemically, is not found in nature like cathinone, which is found in the khat plant Catha edulis. It was discovered in 2014 and attracted attention due to its stimulant effects, which are said to be comparable to those of mephedrone and, to a lesser extent, cocaine and MDMA.

3-CMC is a controlled substance in many countries and has been sold online as a designer drug, primarily in European countries like Poland, Germany, the Netherlands, and Sweden.

3cmc Classification in Europe and USA

The European Monitoring Centre for Drugs and Drug Addiction has classified 3-Chloromethcathinone (3-CMC), a synthetic cathinone, as a new psychoactive substance (NPS).

Although 3-CMC has become more common in the recreational drug market since 2014, there is still a dearth of scientific research on the drug.

The European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) reports that buy 3-CMC has been found in 25 European countries, with the majority of drug seizures occurring in Poland and the Netherlands having the largest amounts. The amount of 3-CMC seized in Europe has increased annually between 2014 and 2021, indicating an increase in production and availability. India is said to be the source of large seizures of 3-CMC by customs.

Chemistry

3-chloromethcathinone (3-CMC) is chemically known as 1-(3-chlorophenyl)-2-(methylamino)-1-propanone. It is a derivative of cathinone that is ring-substituted and N-alkylated. The medication is a bupropion analog in which an N-methyl group has been added in place of the N-tert-butyl group. 3-chlorocathinone(3-CC). is another similar compound.

Effect

Users report fewer effects and shorter durations compared to 3-MMC, which is said to have similar perceived impacts. Increased libido, confidence, and sociability are among the effects, along with stimulation and euphoria. It can be either taken orally or through nasal insufflation.

Depending on how 3-CMC is administered, the acute effects can last anywhere from one to four hours.  Effects, such as insomnia, may persist for three to twelve hours.

Drugs and Medicines

3-CMC’s pharmacology is anticipated to be quite comparable to that of other mephedrone analogs, or methcathinones. Monoamine transporters, specifically the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT), are impacted by these substances. These transporters’ primary job is to stop monoamine transmission by reabsorbing the neurotransmitters that have been released. When psychoactive substances interact with monoamine transporters, they prevent this reuptake. This raises the levels of serotonin, dopamine, and norepinephrine in the synaptic cleft.

Furthermore, mephedrone analogs such as 3-CMC are monoamine-releasing agents (MRAs). The monoamine transporters carry them into the cytoplasm of the nerve terminal, where they enhance the release of monoamine neurotransmitters.

Since they increase the pool of neurotransmitters available for release, releasers are believed to be more effective at increasing monoamine levels. Psychostimulants have varying relative affinities for SERT, DAT, and NET. In a study conducted on male rat brain cells, 3-CMC was found to interact with SERT much less than mephedrone. However,  it was on a level that was comparable to DAT and NET.

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